The samples were analyzed for the CYP1A2 rs762551 single-nucleotide polymorphism. Caffeine is one of the most consumed psychoactive stimulants in the world [1]. PharmGKB summary: very important pharmacogene information for CYP1A2. We propose that in some contexts, improvements in the overall quality of the performed repetitions may be more important for training adaptations than simply performing a greater number of repetitions. Diaz-Lara FJ, Del Coso J, García JM, Portillo LJ, Areces F, Abián-Vicén J. Caffeine improves muscular performance in elite Brazilian Jiu-jitsu athletes. This study adds to the body of evidence showing improvements in muscle endurance following caffeine ingestion [28,29,30,31,32]. Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450. The CYP1A2 rs762551 C allele is associated with lower CYP1A2 enzyme activity. Besides the total number of repetitions, we also measured velocity and power output for each repetition using the linear position transducer attached to the barbell. Cookies policy. The association between daily caffeine intake together with CYP1A2*1F (AA versus CA and CC) genotype and RPL was assessed. CYP1A2 is the main caffeine-metabolizing enzyme. In the responses recorded immediately post-exercise, we found a significant difference between the placebo and caffeine conditions only in items “Increased vigor/activeness” and “Perception of improved performance” in the AC/CC genotypes (Table 3). Before starting the exercise session, in the placebo and caffeine conditions, respectively, 62% and 54% of the participants with the AA genotype correctly guessed the treatment identity beyond chance. Caffeine absorption from tea and coffee is similar 18. CYP1A2*1F haplotype which confers a faster capacity to metabolize caffeine on AA homozygotes [25]. Pharmacogenomics J. Pharmacogenetics. CYP1A2 is an enzyme found primarily in the liver that affects the metabolism of substrates such as estradiol (estrogen), propranolol (heart medication), caffeine and Cymbalta (antidepressant). For this study, we reported the data from this index as a percentage of individuals who identified the correct treatment condition beyond chance [19, 26]. ZP, DJB, CP, BJS, and PM critically revised the manuscript. The Wingate test was performed using a Lode Excalibur Sport Cycle Ergometer (The Netherlands, Groningen). The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes.. Methods. PharmGKB summary: very important pharmacogene information for CYP1A2. Conversely, research has found people with the C allele are slow caffeine metabolizers meaning it takes their body longer to break down caffeine which can lead to a stronger response to caffeine. J Int Soc Sports Nutr. Caffeine and exercise: metabolism, endurance and performance. Placebo effects of caffeine on maximal voluntary concentric force of the knee flexors and extensors. Saunders B, de Oliveira LF, da Silva RP, de Salles PV, Gonçalves LS, Yamaguchi G, Mutti T, Maciel E, Roschel H, Artioli GG, Gualano B. If you are struggling with focus or sleep quality, take a look at your caffeine genes in your. Grgic J, Grgic I, Pickering C, Schoenfeld BJ, Bishop DJ, Pedisic Z. It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. Grgic J. Caffeine ingestion enhances Wingate performance: a meta-analysis. (1999). The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. Now what? Google Scholar. McLellan TM, Caldwell JA, Lieberman HR. We believe that the pre-exercise responses are of greater importance, given that the improvements during the testing session (or lack thereof) may influence the post-exercise responses. The association of caffeine consumption with hypertension remains controversial. He received no financial incentives for the preparation of this manuscript. All analyses were performed using the Statistica software (version 13.4.0.14; TIBCO Software Inc., Palo Alto, CA, USA). Of the whole sample, 13, 7, and 2 participants were categorized as having the AA, AC, or CC genotype, respectively. Springer Nature. The enzyme CYP1A2 is responsible for metabolizing caffeine in the body and determines whether the individual is a slow or a fast caffeine metabolizer. Cyp1A2 encodes cytochrome P450 superfamily of enzymes nucleotide polymorphism, rs762551, within this gene [ 8 ],,. 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